Metabolism and Absorption of Nickel When nickel enters the body it is distributed to all organs, but mostly in the kidney, bone, and lungs (Samal and Mishra, 2011). Cancer: Prolonged exposure to nickel, when seen as an occupational hazard, my result in cancer of nose and throat. Nickel has been found to have some adverse systemic effects on the body. Certain amounts of nickel are useful to the human body, but too much nickel can be toxic. Health effects. Preventing nickel levels in the body from getting too low (nickel deficiency). Exposure to nickel may lead to cancer. Respiratory Conditions: Exposure to nickel may also cause systemic effects. A nickel allergy is the body’s adverse immune response when someone comes into contact with a product containing nickel. Nickel is a common metal that can cause many of these problems. Normally, the adult body contains about 10mg of nickel. Inhalation of nickel also can cause cancer of the lungs, nose and sinuses. Normally, the immune system defends the body … General Nickel Toxicity Information Nickel is a silver-white metal found in the earth’s crust that is used to produce steel, nickel-cadmium batteries, heating fuel, nickel plating and ceramics. Nickel deficiency has not been reported in people, although it may exist, since nickel deficiency has been seen in animals. About 10% of women and 2% of men are highly sensitive to nickel. Chronic noncancer health effects may result from long-term exposure to relatively low concentrations of pollutants. Nickel deficiency can cause diseases such as diabetes, anemia, cirrhosis, uremia, renal failure, abnormal metabolism of liver lipids and phospholipids. If you've been exposed to large amounts of nickel, and believe it to be affecting your health, it is important to take proper measures to get your body back in balance. Exposure can harm the lungs, stomach, and kidneys. The patient may experience asthma attacks, pulmonary fibrosis , and chronic bronchitis . If nickel enters the body with nickel contaminated air it is retained in the lungs. The level of exposure depends upon the dose, duration, and work being done. Nickel (Ni) is a hard, silvery-white metal that may cause irritation to the skin. The aim of this paper is to discuss the sources of Nickel in the body as well as the systemic adverse effects of Nickel as a degradation product of stainless steel surgical implants. Taking trace amounts of nickel in a supplement is effective for preventing nickel deficiency. First, nickel causes essential metal imbalances and severely disrupts enzyme action and regulation. Nickel, which enters the blood stream is Note: The health effects are highly dependent on the manner and degree of exposure and on the exact chemical 'species' in which the nickel atoms are present.The allergic effects tend to arise from the Nickel cation Ni ++, but it is not entirely clear which chemical species is reponsible for the carcinogenic effects noted much more commonly in the past. Nickel is an essential element of the human body, and its content is extremely small in the human body. The Effects of Nickel on Human Health. (9) Once it enters the body, nickel targets a number of organs, including the kidneys, lungs, and liver, and produces multiple toxic effects (9, 13). Workers may be harmed from exposure to nickel. Some of these toxic symptoms include: It also contributes to a high amount of oxidative stress. In people, although it may exist, since nickel deficiency effects of nickel on the body useful to human... 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